Lyme disease recovery often requires more than just antibiotics and herbal treatments. Incorporating high-quality dietary supplements can enhance your treatment and potentially accelerate your healing process.
How Supplements Can Aid Lyme Disease Recovery
Antibiotics and herbal protocols are essential for combating Lyme disease. However, they do not address several critical physiological factors necessary for long-term recovery, including:
- Chronic Inflammation: Lyme disease and co-infections trigger widespread inflammation, affecting the brain, gut, and joints. Research underscores the importance of reducing inflammation to support recovery (1,2,3).
- Nutrient Deficiencies: Chronic illness depletes nutrients such as vitamin D, magnesium, and B vitamins. Proper supplementation is crucial for replenishing these nutrients.
- Gut Imbalances: Lyme infections and antibiotics can disrupt gut health, leading to dysbiosis and yeast overgrowth. Prebiotics and digestive enzymes are often beneficial.
- Detoxification: As Lyme bacteria are killed off, they release toxins that must be efficiently eliminated. Supporting the body’s detoxification pathways can alleviate die-off symptoms.
Below are six foundational supplements that can help reduce inflammation, correct nutrient deficiencies, restore gut balance, and support detoxification.
1. Vitamin D
Approximately 42% of U.S. adults are deficient in vitamin D (source). This vitamin is essential for immune function and inflammation regulation (source). Notably, Borrelia burgdorferi, the bacterium responsible for Lyme disease, may reduce vitamin D receptor expression, increasing the body’s requirement for this vitamin (source).
To maintain serum vitamin D levels between 40-60 ng/mL, partner with a healthcare provider to determine your optimal dosage. Balance vitamin D intake with vitamin K2, which regulates calcium metabolism.

2. Magnesium
Research shows that up to 50% of the U.S. population is deficient in magnesium (source). Chronic stress from Lyme disease further depletes magnesium, exacerbating symptoms such as fatigue, anxiety, insomnia, and muscle weakness. Adequate magnesium intake is also crucial for the proper use of vitamin D (source).
Supplementing with magnesium glycinate, malate, or threonate can improve energy, mood, and sleep. Magnesium threonate, in particular, crosses the blood-brain barrier and supports brain health.

3. N-Acetylcysteine (NAC)
NAC is a precursor to glutathione, a crucial antioxidant that helps the immune system fight Borrelia burgdorferi (source). Glutathione also plays a vital role in detoxification (source). By boosting glutathione levels, NAC may alleviate die-off reactions during Lyme treatment.

4. Probiotics
Antibiotics used to treat Lyme disease can disrupt gut flora, leading to gastrointestinal symptoms and promoting leaky gut. Probiotics help restore gut balance and protect against yeast overgrowth. Look for a probiotic containing at least 10 billion CFUs from the Lactobacillus and Bifidobacteria families. Saccharomyces boulardii is particularly effective in preventing Candida overgrowth during antibiotic treatment (source).

5. Balance Oil
Omega-3 fatty acids, particularly EPA and DHA, have potent anti-inflammatory effects (source). These essential fatty acids can alleviate inflammation in the brain, joints, and gut triggered by Lyme disease. While eating wild-caught seafood is ideal, a Balance oil supplement provide a concentrated source of omega-3s alongside the polyphenols needed to transport it along the food chain to where it is effective in your body, plus sourced and screened for contaminants.

6. Sulforaphane
Sulforaphane, a compound found in cruciferous vegetables, has anti-inflammatory effects on the brain (source). It may help alleviate brain fog, a common symptom of Lyme disease. Sulforaphane also supports detoxification pathways (source). Because the body’s ability to produce sulforaphane from vegetables is variable, stabilised sulforaphane supplements are a reliable option.
Final Thoughts
High-quality supplements can significantly enhance Lyme disease recovery by reducing inflammation, replenishing nutrients, supporting gut health, and aiding detoxification. To ensure you’re getting effective products, purchase supplements from reputable brands such as Pure Encapsulations and Thorne Research. Avoid unreliable sources that may sell adulterated products.
By investing in high-quality supplements, you are making a valuable investment in your health that can yield long-term benefits.